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Ordinary Re-Weighting | RBC Biotech Opportunities NTR Index Series 2 | Effective Date 2nd January 2024

RBC Biotech Opportunities NTR Index Series 2:

In the ordinary re-weighting, the following composition will be implemented effective open 2nd January 2024:

ABBVIE INC
AGIOS PHARMACEUTICALS INC
ALNYLAM PHARMACEUTICALS INC
AMGEN INC
BIOGEN INC
GILEAD SCIENCES INC
INCYTE CORP
INTRA-CELLULAR THERAPIES INC
KARUNA THERAPEUTICS INC
ELI LILLY & CO
PACIRA BIOSCIENCES INC
SAREPTA THERAPEUTICS INC
XENON PHARMACEUTICALS INC