Acquisition | SHIRE PLC | 24th December 2018

Due to the acquisition of SHIRE PLC by TAKEDA PHARMACEUTICAL, the following treatment will be applied to the following indices.

Solactive Equileap Europe Gender Equality Index

Inspire Global Hope Large Cap Equal Weight Index

Solactive ARC ESG Big Data Europe Index

Solactive Future Pharmaceutical Europe Index

Solactive Sustainability Index Europe

Solactive UK 100 Equal Weight 5% AR Index

Solactive Pharma Breakthrough Value Index

Solactive Europe Total Market 675 Index

Solactive European Equity Price Index

• SHIRE PLC will be removed from the Index.
• The weight of SHIRE PLC based on its last close price will be distributed pro rata to remaining Index constituents.
• Effective Date (open): 12/24/2018.

Solactive Global Equity Price Index

Solactive Sustainable World Equity Index

• SHIRE PLC will be removed from the Index.
• The shares of TAKEDA PHARMACEUTICAL will be increased according to the stock terms of the transaction.
• The cash portion of the transaction will be distributed pro rata to remaining Index constituents.
• Effective Date (open): 12/24/2018.