Acquisition | ORCHARD THERAPEUTICS PLC | 24th January 2024

Initially announced on October 6, 2023 KYOWA KIRIN CO LTD made a cash offer for ORCHARD THERAPEUTICS PLC of USD 16 per ORCHARD THERAPEUTICS PLC share held. ORCHARD THERAPEUTICS PLC shareholders approved the Acquisition on December 19, 2023. Trading in shares of ORCHARD THERAPEUTICS PLC is expected to be halted effective January 24, 2024. Due to the presence of a contingent value right in the offer, ORCHARD THERAPEUTICS PLC will be removed pro rata at its last close price effective (open) January 24, 2024.

The treatment below will be applied to the following indices:

• ORCHARD THERAPEUTICS PLC will be removed from the Index.
• The weight of ORCHARD THERAPEUTICS PLC (ORTX.OQ) based on its last close price will be distributed pro rata to remaining Index constituents.
• Effective Date (open): 24/01/2024

Solactive United States Biotechnology Index NTR
Solactive United States Biotechnology Index PR
Solactive United States Biotechnology Index TR
Solactive US Extended Broad Market Index (GTR)