Ordinary Adjustment | Solactive Pharma Breakthrough Value Index | September 2018

In the ordinary rebalancing the following composition will be implemented:

BTG PLC
CELGENE CORP
EXELIXIS INC
SPECTRUM PHARMACEUTICALS INC
NOVARTIS AG
ROCHE HOLDING AG
SHIRE PLC
INCYTE CORP
LIGAND PHARMACEUTICALS INC
H LUNDBECK AS
VERTEX PHARMACEUTICALS INC
BIOGEN INC
ALEXION PHARMACEUTICALS INC
IONIS PHARMACEUTICALS INC
UNITED THERAPEUTICS CORP
CSL LTD ORD
BIOMARIN PHARMACEUTICAL INC
SWEDISH ORPHAN BIOVITRUM AB
IPSEN SA
NIPPON SHINYAKU CO LTD
HALOZYME THERAPEUTICS INC
JAZZ PHARMACEUTICALS PLC
MALLINCKRODT PHARMACEUTICALS
AMAG PHARMACEUTICALS INC
GRIFOLS SA CLASS A
PTC THERAPEUTICS INC
BUKWANG PHARMACEUTICAL CO
MESOBLAST LTD ORD
ARBUTUS BIOPHARMA CORP
AGIOS PHARMACEUTICALS INC
HORIZON PHARMA PLC
RETROPHIN INC
BEIGENE LTD-ADR
EAGLE PHARMACEUTICALS INC/DE